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Saturday, April 21, 2012

Abanico (Antiproliferative / Anticancer/Antifungal )etc

Studies 

• Antiproliferative / Anticancer: Phenolic constituents of rhizomes of the Thai medicinal plant with proliferative activity for two breast cancer lines – Three new compounds were identified– belalloside A, belalloside B and belamphenone along with other compounds resveratrol, iriflophenone, irisflorentine, tectoridin, among the 13 others. Results showed two isolates to have proliferation stimulatory activity against human breast cancer cell lines..
Used for purifying the blood, for liver and pulmonary complaints.
In Malaya, used as a remedy for gonorrhea.
In Malabar, used as alexipharmic.
In Cochin-China (Vietnam), roots used for aperient and resolvent properties.
In traditional Chinese medicine, used for pharyngitis, tonsillitis, cough, wheezing, bronchitis and mumps.


• Antifungal: A study on the antifungal activity of Belamcanda chinensis isolated a compound identical to tectorigenin (5,7-dihydroxy-3-(4-hydroxy phenyl)-6-methoxy-4H-1-benzopyran-4-one). This compound showed marked antifungal activity against dermatophytes of the genera Trichophyton.
• Phytoestrogens / Anticancer: Study demonstrated a role for tectorigenin and irigenin in regulating the number of prostate cancer cells by inhibition of proliferation through cell cycle regulation.
• Hepatoprotective / Antioxidative: Study of tectorigenin and tectoridin isolated from BC rhizomes was shown to have antioxidative and hepatoprotective activities in CCl4-intoxicated rats. 
• Aldose Reductase Inhibition / Tectoridin / Antidiabetic: Aldose reductase is the key enzyme in the polyol pathway, and plays an important role in diabetic complications. Study isolated 12 phenolic compounds from the rhizomes of B. chinensis, with tectoridin and tectorigenin exhibiting the highest aldose reductase inhibitory potency. Administered in STZ-induced diabetic rats, it showed significant inhibition of sorbitol accumulation in the lens, RBC and sciatic nerves. 
• Irigenin / Anti-Inflammatory: Study investigated the anti-inflammatory effects of six flavanoids isolated from the rhizomes of Belamcanda chinensis. Irigenin exhibited concentration-dependent inhibition of LPS-induced nitric oxide (NO) and prostaglandin (PGE2) production.
• Tectorigenin / Prostate Cancer: Study of showed who tectorigenin and other compounds extracted from B. chinensis can significantly rectify the aberrant expression of genes involved in prostate cancer. Irigenin from the rhizomes presents as a leading compound for anti-inflammation.
• Isoflavonoids / Antioxidant / Antimutagenic: Isoflavonoid fractions from a methanolic extract of BC rhizomes inhibited chemically induced mutations in S typhimurium TA98 and TA100 and also showed capability to scavenge free radicals. Results suggest additional value of the plant as a phytoestrogenic and chemopreventive agent.

Uses
Rhizomes used as expectorant.

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